9 Health Benefits of Tocotrienols: Insights from Dr. Barrie Tan’s Research

9 Health Benefits of Tocotrienols: Insights from Dr. Barrie Tan’s Research

Tocotrienols, a form of Vitamin E, have gained significant attention in the scientific community, largely thanks to the pioneering research of Dr. Barrie Tan. His extensive studies and clinical trials have illuminated tocotrienols’ unique properties and health benefits.


Dr. Barrie Tan’s Research on Tocotrienols


  1. Tocotrienols vs. Tocopherols: Tocotrienols and tocopherols are members of the vitamin E family, a group of fat-soluble antioxidants essential for human health. While tocopherols are more widely recognized and researched, tocotrienols are gaining attention for their unique properties. Tocotrienols differ structurally from tocopherols, which impacts their functionality and efficacy. 

Notably, tocotrienols exhibit superior antioxidant capabilities compared to tocopherols. This enhanced potency is attributed to their ability to penetrate cellular membranes more effectively, offering robust protection against oxidative stress. 


Additionally, tocotrienols have been observed to have distinct health benefits that are not as pronounced with tocopherols, including improved cardiovascular health and potential anti-cancer properties. 


Their natural distribution also varies, with tocotrienols being less abundant than tocopherols in most food sources. This comparative rarity adds to the intrigue surrounding tocotrienols as research continues to uncover their potential in health and disease prevention.


  1. Health Benefits: Dr. Tan’s research, encompassing over 100 studies and clinical trials, reveals that tocotrienols offer a range of health advantages:

  • Cardiovascular Health: They support healthy cholesterol levels, reduce inflammation, and promote cardiovascular well-being​​.
  • Neuroprotection: Tocotrienols potentially aid in preventing cognitive decline and neurodegenerative diseases due to their ability to cross the blood-brain barrier​​.
  • Bone, Skin, and Metabolic Health: They contribute to bone, skin, and metabolic health​​.

  1. Dosage and Safety: Clinical trials suggest a daily dose of 100-200 mg of tocotrienol offers adequate lipid antioxidant protection. However, a higher intake of 300-600 mg daily is recommended for addressing specific health conditions. 

Studies have shown that consuming up to 900 mg of tocotrienol daily is safe for 24 months. This dosage regimen demonstrates tocotrienol’s potential in therapeutic applications, especially in managing diseases linked to oxidative stress and lipid imbalances. Such dosages are considered well-tolerated and effective, providing a significant antioxidant boost.


  1. Delta and Gamma Tocotrienols: Delta and Gamma tocotrienols, among the different forms of tocotrienols, stand out for their exceptional potency. This distinction is central to the formulations of Wellness Extract’s products, inspired by Dr. Tan’s extensive research in the field. 

Products like DeltaGold® exemplify this focus, containing a carefully calibrated blend of 90% Delta-Tocotrienols and 10% Gamma-Tocotrienol. This ratio is designed to maximize the health benefits of tocotrienols. Delta and Gamma tocotrienols are noted for their superior antioxidant properties and potential health benefits, including cardiovascular health support, neuroprotection, and NAFLD protection. 


By prioritizing these forms, Wellness Extract’s offerings aim to provide a more targeted and practical approach to harnessing the full therapeutic potential of vitamin E. This approach reflects a growing recognition in nutritional science of the nuanced differences between vitamin E forms and their unique impacts on human health.


  1. Annatto-Derived Tocotrienols: Dr. Tan’s groundbreaking research has brought to light the unique properties of the Annatto plant, distinguishing it as the sole natural source that exclusively contains Delta and Gamma Tocotrienols. This exclusivity positions Annatto-derived tocotrienols as a pure and concentrated form of vitamin E, devoid of tocopherols. 

The absence of tocopherols in Annatto-derived products like Delta and Gamma Tocotrienols enhances their efficacy, making them highly sought for their potent antioxidant properties and potential health benefits.


This specificity of the Annatto plant in offering only Delta and Gamma Tocotrienols underlines its significance in nutritional science and supplements. It provides a specialized source for those seeking the specific health advantages associated with these forms of vitamin E without the interference of tocopherols.


  1. Safety and Regulatory Compliance: Tocotrienols, especially those derived from the Annatto plant, have established a strong safety profile, with no known or documented side effects reported in clinical studies. This safety assurance is further strengthened by the rigorous third-party testing that products like Eannatto DeltaGold Tocotrienol undergo. Such testing is critical in ensuring these supplements’ purity and efficacy. 

  1. Triglyceride Management: Recent studies have shed light on the potential role of tocotrienols in managing triglyceride levels. These findings suggest that tocotrienols may exert a modest yet significant impact on triglyceride concentrations in the body. The mechanism behind this effect involves inhibiting enzymes that play a crucial role in synthesizing triglycerides.

This action of tocotrienols contributes to their broader profile as beneficial compounds in metabolic health. Tocotrienols offer a promising avenue for managing elevated triglyceride levels, a common risk factor for cardiovascular diseases. 


This emerging area of research highlights the multifaceted benefits of tocotrienols, extending beyond their well-known antioxidant properties to include potential roles in lipid metabolism regulation.


  1. Anti-inflammatory Properties: Tocotrienols are increasingly recognized for their potent anti-inflammatory properties, making them valuable in managing various inflammatory conditions. These properties stem from their ability to modulate key inflammatory pathways and molecules within the body. 

The anti-inflammatory action of tocotrienols contributes to their overall health benefits, particularly in conditions where inflammation plays a central role. This includes chronic diseases like arthritis, cardiovascular diseases, and neurological disorders. 


The potential of tocotrienols in reducing inflammation is a significant aspect of their therapeutic profile, offering a natural and effective means of managing inflammation. Their role in mitigating inflammation further complements their antioxidant capabilities, positioning tocotrienols as versatile and beneficial compounds in health and nutrition.


Further Learning!

Dr. Tan’s research has opened new avenues in understanding the potential of tocotrienols in promoting health and preventing diseases. His work emphasizes the importance of tocotrienols as a significant part of patient care, particularly in cardiovascular health, neuroprotection, and chronic illness management.


 Dr. Tan’s informative videos and book “The Truth about Vitamin E” are highly recommended for those interested in delving deeper into this topic​​.

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