Possibly the most useful supplement I have ever taken with the exception of the basic vitamins and minerals. Long story short, this supplement makes me feel 20 years younger and cures a chronic neck/shoulder/trap pain I’ve had for 15 years. I stopped taking it for a few weeks to confirm the results. Upon restarting about a week later agin feeling young vital and pain free. I take 2 pills a day, as that is close to the dose recommended by Dr Barrie Tan the scientist who discovered it in annatto. If I could give it 10 stars I would.