Heart Health for Women Over 45: Can Tocotrienols be the Rescuer?

Women’s health goes through so many changes, RIGHT? From puberty to pregnancy to menopause, there’s a lot happening in the body over the years. But there’s one big change that doesn’t get the attention it deserves— the risk of heart disease for women at the age of 40- 45.

As women age, especially after 45, maintaining heart health becomes even more crucial. Unfortunately, heart disease is the leading cause of death, & for women, it’s often underdiagnosed. Here’s why: Before menopause, estrogen plays a protective role for the heart. But once menopause kicks in, that protection starts to fade, increasing the cardiovascular risk. But here’s the good news—there’s a potential nutrient called tocotrienol (a form of vitamin E) that could be a game-changer for heart health. Studies show tocotrienols may help protect the heart & improve blood flow.

In this blog, you’ll learn about:

  • How menopause affects heart health

  • Why tocotrienols are great for heart health

Let’s dive in & explore how to keep the heart healthy as the years go by!

A Quick Look at Changes Women Experience After 45

As women move into their mid-40s and beyond, they experience several physical changes, many of which can impact heart health. Understanding the broader picture helps explain why these changes matter. 

Here is what WHO says: Cardiovascular diseases (CVD) are the leading cause of death worldwide, causing about 31% of all deaths, or around 17.9 million people each year. Cardiovascular diseases include coronary heart disease, stroke, & peripheral arterial disease (a condition where blood vessels that supply blood to the legs or arms narrow or become blocked). 

Moreover, studies show that while low estrogen levels are linked to coronary artery disease in men, the risk significantly increases for women after menopause. This makes it essential for women to prioritize their heart health during and after this transition.

Let’s break down some key changes women go through after 45 & why it’s important to stay informed & take action when it comes to heart health.

1. Hormonal Changes & Coronary Heart Disease (CHD)

During menopause, estrogen levels drop, & women lose the heart-protective effects that hormones once offered.  Epidemiological studies state women usually develop coronary heart disease (CHD) later than men, but after menopause, the risk increases a lot. Postmenopausal women are more likely to have stable plaques (deposition of bad fat) & microvascular issues (small blood vessels in the body are affected). So, while women get heart disease a bit later than men, the risks really rise after menopause.

2. Blood Pressure: Hypertension’s Growing Threat

As women get older, high blood pressure (hypertension) becomes more common, especially after menopause. The changes in hormone levels & metabolism that happen with age can directly impact blood pressure, which tends to rise more in postmenopausal women. High blood pressure can make the blood vessels stiffer, which increases the risk of heart disease & stroke. Women who go through early menopause (before age 40) are at a higher risk for high blood pressure & heart problems because of the longer time without estrogen.

3. Cholesterol Imbalances

After 45, many women notice changes in their cholesterol levels. Total cholesterol, LDL ("bad" cholesterol), & triglycerides tend to go up, while HDL ("good" cholesterol) goes down. These shifts increase the risk of atherosclerosis (thickening or hardening of the arteries) & other heart diseases. Postmenopausal women are 2-3 times more likely to develop metabolic syndrome than premenopausal. Metabolic syndrome is a cluster of health conditions including low good cholesterol and high bad cholesterol. Hence, monitoring cholesterol levels helps manage this syndrome and identify potential complications.

4. Abdominal Fat & Heart Health

As metabolism & hormone levels shift, many women gain abdominal fat after 45. This kind of fat is especially concerning because it’s linked to heart disease, insulin resistance, & other health risks. Studies show postmenopausal women are more likely to have central obesity, raising the risk of type 2 diabetes & hypertension—both big contributors to heart disease.

5. Diabetes & Metabolic Changes

The risk of type 2 diabetes goes up as women approach & go through menopause. Insulin resistance and higher blood sugar levels become more common, especially with weight gain and hormonal changes. The mix of metabolic syndrome, obesity, & diabetes increases the risk of heart disease & stroke. The good news is that managing diet & exercise can help reduce these risks.

6. Genetics Matter Too

Did you know genetics can influence when you go through menopause? Menopause usually happens between ages 40 and 60, and research shows the timing can affect your heart health. Genetics plays a big role in when menopause occurs, with studies showing a heritability range of 31% to 87%

Women who experience early menopause (before age 40) are at a higher risk of heart disease, including coronary artery disease and other risk factors like higher BMI and waist size. This highlights the importance of Heart health checks with consideration of genetic factors, along with gender-specific risks in postmenopausal cardiovascular health.

Changes Women Experience After 45

Heart Health for Women Over 45: Tocotrienols to the Rescue!

Understanding the changes women experience after 45 makes it clear that prioritizing heart health is crucial. One promising nutrient that may help is tocotrienols, a form of vitamin E. So, why are tocotrienols great for heart health? Let’s take a closer look.

Quick Stats on Heart Disease

Heart disease is the leading cause of death worldwide. According to the World Health Organization (WHO), heart disease and stroke cause about 17.9 million deaths each year, and this number is expected to rise to over 23 million by 2030. In the U.S., more than a million people die from heart disease every year.

 With heart disease being such a major issue, finding natural treatments like tocotrienols is more important than ever.

What Makes Tocotrienols Unique for Heart Health?

Tocotrienols are a form of vitamin E, distinct from the more commonly known tocopherols.There are four types: alpha, beta, gamma, & delta. Each type offers different benefits for heart health, with gamma-tocotrienol being especially effective in protecting the heart. What makes tocotrienols unique for heart health is that they can cross cell membranes more easily than tocopherol, which means they’re even more powerful in supporting heart health.

Why Are Tocotrienols Gaining Attention?

For years, tocopherols (the standard form of vitamin E) were widely recognized for heart health benefits. However, emerging research suggests that tocotrienols may be even more effective at:

  • Lowering cholesterol

  • Reducing inflammation

  •  Enhancing heart protection

With heart disease being a major concern for women after menopause, tocotrienols could play a vital role in maintaining heart health.

What Do Tocotrienols Offer for Heart Health?

As women age, particularly after menopause, the risk of heart disease increases. Research highlights that tocotrienols may offer superior heart supporting benefits compared to regular vitamin E by:

  • Protecting the heart

  • Improving blood flow

  • Lowering bad cholesterol

  • Reducing inflammation. 

With heart health becoming a priority post-menopause, tocotrienols could be better natural nutrients for maintaining it.

You might be wondering where to find this miracle supplement. Well there are many sources of tocotriobols including palm oil, rice bran oil, and barley. However, Annatto, stands out as the most significant source of tocotrienols. It exhibits many qualities that could be beneficial for heart health. Let's look at the 4 key ways Annatto tocotrienol can help protect your heart.

4 Major Cardiovascular Benefits of Annatto Tocotrienol

Annatto tocotrienol has shown a lot of potential for heart health. Let’s take a look at the 4 main benefits:

1. Lowering Cholesterol

High cholesterol is one of the major risk factors for heart disease, affecting about one-third of adults in the U.S. Studies going back to the 1980s, including ones from the University of Wisconsin, have shown that tocotrienols can help lower cholesterol, especially LDL (the “bad” cholesterol). Annatto tocotrienols (a dose of 250mg) have been shown to lower total cholesterol by 15%, LDL cholesterol by 18%, & triglycerides by 14% in just 4 weeks. So, if you're looking for a natural way to manage cholesterol, annatto tocotrienols could be a great option.

2. Reducing Inflammation

Even if your cholesterol levels are normal, inflammation can still cause heart problems. Tocotrienols, especially delta-tocotrienol, have the potential for anti-inflammatory effects. Studies have found that tocotrienols can lower C-reactive protein (CRP), an inflammatory marker, by up to 40%. By reducing inflammation, tocotrienols help prevent plaque buildup in the arteries, which can lower the risk of heart disease & stroke. What is more exciting is that there were no adverse effects related to the 6-week tocotrienol supplementation period.

3. Preventing Plaque Buildup

Plaque buildup in the arteries (known as atherosclerosis) is a serious issue that can lead to heart problems. As per the studies, Annatto tocotrienols could have the potential to reduce plaque buildup (buildup of fatty substances in arteries). In one study, patients with carotid arteriosclerosis saw improvements after taking tocotrienol supplements. Cholesterol dropped by 14%, & LDL went down by 21%. This shows that tocotrienols might help prevent or even reverse plaque buildup in the arteries, which is key in heart disease prevention.

4. Hypertension (High Blood Pressure)

Hypertension, also known as high blood pressure, is often called the "silent killer" because it can go unnoticed. About 32% of adults in the U.S. have it. Tocotrienols have shown promise in reducing blood pressure by improving how the arteries function. Gamma-tocotrienol is particularly effective in lowering blood pressure.

Note: All the above-mentioned studies of tocotrienols on heart health are still in their early phases and need more clinical studies for their long-term safety. Do not take it as an alternative to professional advice or any ongoing treatment.

Conclusion: Potential of Tocotrienols for Supporting Heart Health

Heart health is a growing concern for women, especially after the age of 45. With the risk factors linked to aging, including hormonal changes, high blood pressure, and cholesterol imbalances, it’s more important than ever to take proactive steps. Tocotrienols, a potent form of vitamin E, could play a vital role in reducing these risks, lowering cholesterol, and protecting the heart from inflammation and plaque buildup. By incorporating tocotrienols into your lifestyle, you’re supporting your heart’s health naturally.

Disclaimer: This blog is intended for informational purposes only. Always consult with a healthcare professional before making any changes to your diet or supplement regimen, especially if you have existing health conditions or are on medication. Heart health requires a multifaceted approach that includes a balanced diet, regular exercise, and routine health checkups.



Read More...

Why Postmenopausal Women Need Vitamin E Tocotrienols

Sleepless nights, aching joints, and a slowing metabolism — familiar symptoms for many women in their 40s and 50s going through menopause or postmenopause.

Menopause might sound like just a biological transition, but it is a state of complete psychological unrest. What’s worse is that even postmenopause, the symptoms sometimes continue. Unpredictable mood swings and getting anxious over little things! At times, even intimacy can feel complicated with hot flashes and vaginal dryness. No doubt, these challenges are overwhelming. But what if nature had a solution?

Recent research highlights the role of annatto-derived vitamin E tocotrienols in supporting postmenopausal health and easing the transition. Sounds interesting, doesn't it? Let's see how tocotrienols empower postmenopausal women.

Menopause and Its Impact on Women

Menopause is not a disease or disorder but a natural part of aging, typically occurring between the ages of 45 and 55. It marks the phase when a woman stops having menstrual periods and can no longer conceive. As the body transitions into postmenopause, the ovaries stop releasing eggs, leading to a significant drop in two essential hormones — estrogen and progesterone — which play a crucial role in feminine health.

This hormonal shift brings about several changes, which can vary for every woman:

  • Bone density loss: An average woman loses about 10-20% of bone density within the first five years of menopause due to declining estrogen levels. The sudden decline in bone density also increases the risk of osteoporosis.

  • Mood fluctuations: Reduced estrogen can trigger mood swings, irritation, and even depression.

  • Cardiovascular risks: Nearly 80% of women face an increased risk of cardiovascular issues once they cross 40.

  • Skin changes: The skin may lose its elasticity and glow, often affecting a woman's confidence and self-image.

Impact of Menopause on Women

Do women really have to cope with these changes, or does nature have a solution to make this transition easier? Let's see what science says about it.

Vitamin E Tocotrienols for Postmenopausal Women

Tocotrienols are not just another supplement—they are scientifically backed all-in-one solutions for postmenopausal women. The current research and studies support the idea that tocotrienols might be a practical and natural approach for women, helping them to age gracefully.

Find out: 11 Reasons Why Tocotrienols Are Vitamin ‘E’ssential

Tocotrienols are a lesser-known yet highly potent member of the vitamin E family. Unlike their counterpart, tocopherols, tocotrienols have enhanced antioxidant and anti-inflammatory properties that make them especially beneficial for women. Here's how:

How Tocotrienols Address Postmenopausal Osteoporosis- A Global Health Concern

Did you know, according to WHO, around 30% of postmenopausal women worldwide have osteoporosis? And, the figures turn more threatening as women age, emerging as a global concern. Estrogen plays a vital role in bone metabolism. It inhibits the activity of osteoclasts, promoting the osteoblasts, a.k.a bone-forming cells.

Hence, a decline in estrogen results in an increase in bone resorption and a decrease in bone formation. It lowers bone density and increases the risk of osteoporosis. Do you know what's worse? According to current statistics, around 50% of postmenopausal women with osteoporosis will experience a fracture related to the condition during their lifetime. In simple words, there is a high chance that a significant portion of women diagnosed with osteoporosis will eventually suffer a painful fracture due to weakened bones.

The statistics highlight the severity of osteoporosis and its consequences. But, there is a bright side. Recent studies show that tocotrienols have bone-protective effects attributed to their antioxidant properties. In a placebo-controlled trial, tocotrienol supplementation led to a significant decrease in urinary N-terminal telopeptide (NTX) levels, which indirectly represents bone damage. Thus, tocotrienol may suppress the bone resorption rate. While tocotrienol potentially offers a novel approach to managing postmenopausal osteoporosis, we still need large-scale human research to evaluate the actual efficacy.

Hidden Postmenopausal Benefits of Tocotrienols Beyond Bone Health

You might be mistaken if you feel that tocotrienols only support women in restoring bone density. In fact, vitamin E tocotrienols are more like a complete health solution for aging women.

Hormonal Harmony

One of the most overlooked impacts of menopause is hormonal imbalance. During menopause, ovaries produce less-than-normal levels of estrogen and progesterone. This transition often causes hot flashes, mood swings, night sweats, vaginal dryness, and bladder concerns among women. Thanks to the anti-inflammatory properties of tocotrienols, they may help alleviate mood swings and other postmenopausal symptoms.

Overall Cellular Health

The presence of free radicals is harmful to everyone. They can interfere with cellular health, resulting in chronic inflammation. However, with a decline in estrogen, postmenopausal women are more susceptible to their adverse effects. Studies report a significant decrease in urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations, a biomarker of DNA oxidative stress, in postmenopausal women receiving tocotrienol supplementation. Thus, by reducing oxidative stress, tocotrienols may improve overall health.

Radiant and Glowing Skin

Another most visible sign of menopause is skin decay. Wrinkles, fine lines, age spots, etc., become common concerns, and every woman wishes for glowing and radiant skin. The powerful antioxidizing capacity of tocotrienols reduces oxidative stress and premature aging. Studies show that tocotrienols also promote skin collagen and support the skin barrier by filtering out harmful UV rays. This is how a regular, safe dose of tocotrienols every day can give you everlasting, supple, and glowing skin.

Boost Metabolism and Cognitive Health

As women age, their metabolism slows, resulting in poor digestion, muscle loss, unpredicted weight gain, fatigue, etc. Vitamin E tocotrienols regulate lipid metabolism and suppress the activity of HMG-CoA reductase (an enzyme that lowers blood cholesterol levels), leading to managed glucose levels. Further, there are preliminary studies suggesting its neuroprotective properties. By preventing the oxidative metabolism of arachidonic acid, tocotrienols may foster brain growth and function, potentially enhancing cognitive health and making postmenopausal women feel mentally sharp and active.

A Healthier Heart

With an overall decline in sex hormones, postmenopause brings cardiovascular risks among women. Tocotrienols react with low-density lipids, a.k.a. bad cholesterols, eliminating their excess from the bloodstream. It also neutralizes free radicals and reactive oxygen species, which are one of the root causes of heart disease. Further, studies show that vitamin E tocotrienols may protect arterial walls from atherosclerotic damage.

Tocotrienols benefits for menopausal women

Isn't it incredible? How perfectly a single natural compound gives postmenopausal women the best of their later years!

A Way Forward

Dear women, menopause is a natural phenomenon, not a battle. You don't have to hold your potential and happiness back. Adding a tiny softgel capsule of vitamin E tocotrienols to your lifestyle can bless you with quality health standards, a healthy heart, strong bones, glowing skin, and a better self. However, it is equally important to choose the best for quick and effective results. Annatto-sourced tocotrienols are considered the best, with 90% delta tocotrienol. Get the one for yourself, and rediscover your vibrant version.

Disclaimer: These statements have not been assessed by the FDA. The information contained within this page is for educational purposes only. It is not intended to replace the advice or attention of health care professionals. Further large-scale clinical trials are necessary to fully understand the therapeutic effects of tocotrienols in the human ecosystem.

 

Read More...

How Tocotrienols Can Help Reduce Fatty Liver: Ideal Dosage and Guidelines

Did you know that Nonalcoholic Fatty Liver Disease (NAFLD) affects millions worldwide—even those who don't consume alcohol? Also known as steatosis, this metabolic dysfunction occurs when excess fat accumulates in the liver. What makes it even more concerning is the lack of a standard treatment. Instead, doctors focus on managing underlying causes like obesity.

But there's a silver lining! Recent research highlights tocotrienols as a promising supplement for supporting liver health. While human-based trials are still limited, studies on various tocotrienol dosages for fatty liver have shown encouraging results. Here's a detailed blog elaborating on the role of tocotrienols in promoting liver health.

Is Your Liver Healthy? A Quick Look at NAFLD

Let's first quickly learn about NAFLD! In the US alone, NAFLD is one of the most common liver disorders, affecting 24% of adults. Also known as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), refers to the medical condition when excess fat accumulates in the liver without considerable alcohol consumption. Common signs of fatty liver include:

  • Slow metabolism

  • Body odor / bad breath

  • Abnormal cholesterol levels

  • Fatigue and low energy levels

At first, NAFLD often goes unnoticed and may damage the liver severely when left untreated for the long term. It is further classified into two types, depending on the inflammation involved:

Nonalcoholic Fatty Liver (NAFL)

NAFL is the condition when the fat in the liver has no or minor inflammation. Generally, it doesn't lead to severe liver damage, but liver enlargement causes discomfort in day-to-day lifestyle.

Nonalcoholic Steatohepatitis (NASH)

NASH accounts for around 1.5% to 6.5% of total NAFLD cases. It involved severe liver inflammation and damage. Though it's rare, it may result in fibrosis, cirrhosis, or even liver cancer when left unnoticed for the long term.

Are you curious about how doctors identify and manage fatty liver disease? That's what is included in the upcoming section.

Current Approaches to Fatty Liver Management

There is no standard treatment for fatty liver. Primarily, it includes lifestyle changes and targeting the underlying causes (diabetes and obesity in the majority of the population). If you actually want to understand how to manage NAFLD, you must first learn about liver health indicators.

Understanding Liver Biomarkers

Liver biomarkers are the key indicators of liver health. Let's learn more about them and how they change in fatty liver diseases.

ALT (Alanine Aminotransferase)

ALT, or Alanine Aminotransferase, is a liver enzyme that converts proteins into energy. When the liver is inflamed or severely damaged, ALT is released into the bloodstream, increasing its level.

FLI (Fatty Liver Index)

Fatty Liver Index (FLI) is a score used to assess fatty liver disease risk. Simply put, it estimates fat accumulation in the liver. A low FLI (<30) suggests a healthy liver. This index also factors in BMI, triglycerides, waist circumference, and gamma-glutamyl transferase (GGT).

hs-CRP (High-Sensitivity C-Reactive Protein)

hs-CRP is the body inflammation biomarker. The liver also produces high-sensitivity C-reactive protein in response to injections, injuries, and chronic diseases. Chronic inflammation often leads to high hs-CRP levels in the body.

MDA (Malondialdehyde)

MDA, or malondialdehyde, is the oxidative biomarker that is formed when free radicals damage cell membranes. The levels of MDA indicate lipid peroxidation in the liver. The higher the MDA levels, the more severe the case.

Now that you know about the indicators of liver health, the next question is: how do tocotrienols help manage fatty liver conditions?

Latest Research on Tocotrienols & NAFLD

For a long time, alpha-tocopherol, the earliest-known form of vitamin E, has been recommended for certain NAFLD patients. However, recent studies show that tocotrienols, with their potent anti-inflammatory and antioxidative properties, may be more effective in reducing liver fat and enzyme levels. It raises a crucial question:

Is tocotrienol really the solution to fatty liver? And, if so, what is the ideal tocotrienols dosage for fatty liver?

To find the exact answer about tocotrienols' ability to lower liver fat, let's look at recent related research.

Animal Studies

Preclinical rodent studies have shown that tocotrienols (an extract derived from palm and annatto) improve liver health. In these studies, rats were first fed a high-carbohydrate, high-fat diet to induce obesity and NAFLD, followed by supplementation with γ- and δ-tocotrienols. This supplementation led to improved liver function, reduced inflammation, and decreased oxidative stress markers.

Human Studies

Similarly, in human trials, tocotrienol supplementation showed promise in improving liver conditions. In a placebo-controlled trial, 71 NAFLD patients were given a high dose of tocotrienols (300 mg) twice for 12 weeks. The supplementation led to significant reductions in liver enzymes, contributing to improvements in liver function, inflammation, and oxidative stress.

Further, annatto-derived delta-tocotrienol, with its high bioavailability and potent antioxidative properties, may target liver fat and inflammation more effectively than other forms. Based on studies, here's how delta-tocotrienols supplementation has regulated liver health:

Impact of Delta-Tocotrienols Supplementation on Liver Health

(ref. 2018 studies)

Liver Biomarkers

What Happens In Fatty Liver

Tocotrienol Effect

Liver Enzymes (ALT)

Excess release in blood, leading toxicity

Significant reduction

Fatty Liver Index (FLI)

High FLI (>60)

Significant reduction

Inflammation (hs-CRP)

Increased levels, contributing liver damage

Notable decrease

Oxidative Stress (MDA)

Increased levels, indicating oxidative damage

Significant decrease


Comparison of liver health markers after delta tocotrienol and placebo

How Tocotrienols Work Against Fatty Liver

Due to the limited human studies, the exact mechanism of action behind tocotrienols' ability to reduce liver fat is still unknown. It might be because of the antioxidative and anti-inflammatory properties of tocotrienols.

Antioxidation

Oxidative stress is a key driver of liver damage in NAFLD. The harmful free radicals interfere with the liver cells, resulting in their degradation. In clinical studies, tocotrienols have shown a reduction in the oxidative damage marker, malondialdehyde (MDA). Being the most potent form of vitamin E, it also increases levels of antioxidant enzymes, including glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD).

Lipid Metabolism Regulation

In research, tocotrienols have regulated lipid metabolism by modulating key enzymes. Tocotrienols inhibit lipogenesis by downregulating SREBP-1c (Sterol Regulatory Element-Binding Protein 1c), thus managing fat synthesis in the liver. Additionally, tocotrienols, particularly delta- and gamma-tocotrienols, activate PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha), enhancing fatty acid oxidation and breaking down stored fat.

Redox Regulation

Tocotrienols also suppress reactive oxygen species (ROS), a form of free radicals that can otherwise damage the liver cells. By directly oxidizing, reactive oxygen species can interfere with the proteins, lipids, and other essential parts of the liver, leading to disruptions in cellular functions. Tocotrienols, due to the presence of chromanol group and unsaturated double bonds, readily donate electrons to ROS and other free radical species, combating their reactivity.

Anti-Inflammation

Chronic inflammation is the key driver behind liver damage. In human-based research, tocotrienols have reduced inflammation by inhibiting NF-κB and other inflammation biomarkers. Additionally, tocotrienol fraction has also reduced pro-inflammatory cytokines like TNF-α and IL-6, improving the overall cellular health.

Additionally, there might be other mechanisms that are indirectly related to liver health. A few studies support the glucose-lowering ability of tocotrienols, which also contribute to liver fat accumulation.

However, the drawback is that the results were inconsistent depending on the type of tocotrienols (palm or annatto-derived) and the severity of obesity.

Now that the possible mechanism of action of tocotrienols is clear, the next question is—how can they be taken for maximum effectiveness in NAFLD?

How to Take Tocotrienols For Fatty Liver

You may include tocotrienols in your regime to enhance your liver health, combat lipid peroxidation, and improve inflammation in the form of softgel capsules for maximum bioavailability.

Important Note: Though tocotrienols in research have shown a potential to improve liver health, the results are inconsistent. Furthermore, while tocotrienol supplementation may adjuvant the standard treatment, they aren't meant to replace the medicines. Supplementation in any form can be a preventative measure but not a cure or treatment.

Tocotrienols Dosage for Fatty Liver

Since the research on tocotrienols and their impact on NAFLD is still on an emerging scale, there has been no valid statement from the WHO or FDA about tocotrienol supplementation and its dosage on liver health. Even in clinical studies, tocotrienols have shown inconsistent impact based on the dosage.

Clinical Studies on Tocotrienol Dosage for NAFLD

Study Reference

Tocotrienol Dosage Administered

How It Is Given

Duration of the Course

Impact on Liver Health

2018

600 mg/day

300 mg twice daily

12 weeks

Improved liver enzymes (ALT, AST), lower inflammation (hs-CRP), reduced oxidative stress (MDA)

2020

400 mg/day

200 mg twice daily

12 months

Significant reduction in liver fat, liver enzymes, and oxidative stress

2023

200-600 mg/day

Varies

Varies

Reduction in liver fat, inflammation, and oxidative stress.

In general terms, you may take a low dose of tocotrienols, 200-300 mg/day, as a preventive measure. However, your doctor might recommend a higher dose based on your medical report. Additionally, even 1000 mg/day of tocotrienol doesn't show any adverse effects on human health.

Also read how much vitamin E is good for your liver.

Best Form of Tocotrienols for Fatty Liver

Tocotrienols are extracted from three primary sources (annatto seeds, palm oil, and rice bran). Tocotrienols exist in four isomers: alpha, beta, gamma, and delta. Each tocotrienol isomer carries its own characteristics. Alpha-tocotrienol is the most bioactive form. However, research suggests that delta-tocotrienol is best known for its potential benefits for liver health.

Along with the ideal dosage, you must also take tocotrienols in the right way to ensure maximum health benefits.

When and How to Take Tocotrienols

Here are a few instructions that you must follow for the given instructions:

  • Always take tocotrienols with meals for enhanced absorption since they are fat-soluble.

  • Split the dosing in two times to maintain healthy cellular levels. Most studies used evening and morning doses.

  • Tocotrienols are not meant to cure or treat any diseases. Pair vitamin E tocotrienols with healthy fats like olive oil, avocados, or nuts and regular exercise for better results.

  • Though tocotrienols are well-tolerated, it is advised to consult a medical professional or doctor, especially if you have existing liver conditions or take medications.

  • High doses (>600 mg/day) may cause mild gastrointestinal discomfort in some individuals.

  • For significant results, you must take tocotrienols for the long term, at least 3-12 months.

Tocotrienols for Fatty liver

What Does The Future Promise

Tocotrienols hold exciting potential for supporting liver health, especially for those with fatty liver! The early findings highlight the antioxidative, anti-inflammatory, and lipid-regulating properties of tocotrienols. Additionally, there are no significant side effects of tocotrienol supplements.

However, it's essential to acknowledge that tocotrienols are not a stand-alone treatment for NAFLD or any other disease but may complement lifestyle changes and medical advice. 

So, what's still stopping you? Consult your physician today to see if they're a good addition to your routine for supporting overall cellular health.

Disclaimer: This content is for informational purposes only and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare professional before using supplements, especially if you have a medical condition or are on medication.

Frequently Asked Questions (FAQs)

Is tocotrienol good for fatty liver?

In research, delta tocotrienols have improved lipid metabolism and prevented liver steatosis. It may also reduce fat accumulation in the liver. However, we need comprehensive preclinical and human studies to predict the exact mechanism.

Which vitamin is best for fatty liver?

Annatto-derived vitamin E delta-tocotrienol is most potent for fatty liver.

Who should not take tocotrienols?

Pregnant women and individuals with bleeding disorders must consult doctors before taking tocotrienols.

What is the tocotrienols dosage for fatty liver?

You may take 200-300 mg of tocotrienols per day to prevent fatty liver. Still, it is best to consult a healthcare provider first.

Sources:

https://link.springer.com/article/10.1186/1475-2891-12-166

https://pmc.ncbi.nlm.nih.gov/articles/PMC6284694/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9965814/ 

https://pubmed.ncbi.nlm.nih.gov/24373555/

https://pubmed.ncbi.nlm.nih.gov/29749323/ 

https://www.mdpi.com/2072-6643/15/4/834 

https://pmc.ncbi.nlm.nih.gov/articles/PMC3681510/ 

https://pmc.ncbi.nlm.nih.gov/articles/PMC8301652/ 

https://www.sciencedirect.com/science/article/abs/pii/S0965229920300777

https://www.sciencedirect.com/science/article/pii/S0965229922000681

https://www.niddk.nih.gov/health-information/liver-disease/nafld-nash/definition-facts

https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.667247/full

https://www.mdpi.com/2072-6643/15/4/834

https://www.sciencedirect.com/science/article/pii/S1756464620304333

https://link.springer.com/article/10.1186/s12887-024-04993-8

Read More...