Dr. Barrie Tan, Ph.D., is one of the world’s foremost experts on Vitamin E. After discovering tocotrienols in three major natural sources (palm, rice, and annatto), Dr. Tan dedicated his life to researching their health benefits.
His groundbreaking work identifying annatto as the only tocopherol-free source of tocotrienols revolutionized our understanding of Vitamin E’s therapeutic potential.
His groundbreaking work identifying annatto as the only tocopherol-free source of tocotrienols revolutionized our understanding of Vitamin E’s therapeutic potential.
With over 50 scientific publications and multiple patents, Dr. Tan’s research has been instrumental in establishing tocotrienols as powerful bioactive compounds with unique benefits for cardiovascular health, metabolism, and cellular protection that far exceed those of conventional Vitamin E.
For over three decades, Dr. Barrie Tan has devoted his life to uncovering the truth about Vitamin E. In this short video, he shares the story behind his discovery of tocotrienols in palm, rice, and annatto—and how this breakthrough changed the way the world understands Vitamin E.
Watch Dr. Tan Explain How the Science of Tocotrienols Began
Identification of annatto as a tocopherol-free tocotrienol source.
Identification of annatto as a tocopherol-free tocotrienol source.
Human studies confirm safety and benefits in key health areas.
International awards and ongoing research.
Tocotrienols have been studied in dozens of human trials and published research worldwide. Here's what the science shows across eight major areas of health and wellness:
Human trials show tocotrienols lower LDL cholesterol, improve arterial flexibility, and support circulation by regulating the HMG-CoA reductase pathway — protecting long-term heart health.
Long-term MRI studies found tocotrienols slow white matter lesion growth, protecting neurons and supporting memory, focus, and cognitive performance as we age.
At 300 mg/day, tocotrienols normalize liver enzyme levels and reduce inflammation, supporting detox, liver balance, and metabolic health.
Research demonstrates tocotrienols enhance lipid metabolism and reduce oxidative stress, helping maintain healthy blood sugar, weight control, and efficient energy production.
Studies show tocotrienols ease oxidative stress during menopause, supporting bone density, cardiovascular protection, and hormonal balance for women’s long-term well-being.
Clinical research shows tocotrienols improve skin elasticity and hydration while protecting against UV and oxidative damage — promoting firmer, smoother, youthful-looking skin.
Clinical research shows tocotrienols improve skin elasticity and hydration while protecting against UV and oxidative damage — promoting firmer, smoother, youthful-looking skin.
Tocotrienols boost mitochondrial efficiency — the cell’s energy powerhouse — improving stamina, vitality, and resilience by reducing oxidative burden inside the cells.
Most “Vitamin E” clinical trials tested only α-tocopherol, leading to inconsistent and disappointing results. This has created confusion in both the scientific community and among consumers.
It’s crucial to understand tocopherols and tocotrienols are fundamentally different in structure and function. While both are Vitamin E, they act very differently in the body.
Research shows α-tocopherol can block tocotrienol absorption by up to 60%, reducing their effectiveness.
Annatto’s clean δ/γ tocotrienol profile avoids this issue entirely — ensuring maximum bioavailability and therapeutic effect.
Annatto is the only source that provides 100% δ/γ tocotrienols with no interfering tocopherols. This makes it the preferred source for modern clinical research.
Palm & Rice Sources: Contain mixed tocopherols, diluting effectiveness and blocking absorption.
Annatto Source: Pure δ/γ tocotrienols, the same profile used in the most successful clinical trials.
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